Download e-book for kindle: A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman

By Eveline S. Litscher, Paul M. Wassarman

ISBN-10: 0470528117

ISBN-13: 9780470528112

ISBN-10: 1119044723

ISBN-13: 9781119044727

ISBN-10: 1119044766

ISBN-13: 9781119044765

ISBN-10: 1119044995

ISBN-13: 9781119044994

This publication offers a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details to be had for the zona pellucida area protein relatives, which effect pathologies reminiscent of infertility, deafness, and melanoma. moreover it:

  • Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
  • Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
  • Speculates as to the evolution of the ZP area and power therapeutics for ailments stemming from ZP area mutations
  • Addresses mammalian and non-mammalian systems

Show description

By Eveline S. Litscher, Paul M. Wassarman

ISBN-10: 0470528117

ISBN-13: 9780470528112

ISBN-10: 1119044723

ISBN-13: 9781119044727

ISBN-10: 1119044766

ISBN-13: 9781119044765

ISBN-10: 1119044995

ISBN-13: 9781119044994

This publication offers a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details to be had for the zona pellucida area protein relatives, which effect pathologies reminiscent of infertility, deafness, and melanoma. moreover it:

  • Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
  • Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
  • Speculates as to the evolution of the ZP area and power therapeutics for ailments stemming from ZP area mutations
  • Addresses mammalian and non-mammalian systems

Show description

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Extra resources for A Guide to Zona Pellucida Domain Proteins

Example text

1 marqalrstl wllpsillcf pfclplsgqh vtelpgvlhc glqsfqfavn lsleaespvl 61 ttwdsqglph rlkndsdcgt wvmdspdgfl vleasysgcy vtlegshyim tvgvqeadva 121 ghvagtrqrl ltcplalqgk apdtpsakvC spvpvkerlp Casstisrgd CeelgCCyss 181 eeegadsCyy gntvtshCtk eghfsiavsr dvtspplrld slrlgfrnit tgCdpvmkts 241 tfvlfqfplt sCgttqritg dqamyenelv airdvqawgr ssitrdsnfr lrvsCtysih 301 simspvnmqv wtlppplpkt qpgplslelq iaqdknyssy ygtdayplvk flqdpiyvev 361 silhrtdpsl sllleqCwat pgsnpfhqpq wpilvkgCpy agdnyqtkri pvqkasdvfp 421 shhqrfsist fsfmsagrek qvlggqvylh CsasvCqpag mpsCtviCpa srrrrksely 481 fdnstsissk gpvillqatk dpavmlhkhs gthadsptlw vmglsasmvi tgvlvvsyla 541 trkqr Further Reading Akatsuka K, Yoshida‐Komiya H, Tulsiani DR, Orgebin‐Crist M‐C et al.

MZP3 vs. , mZP3 vs. 1). ZPD proteins that have diverse functions are found in every major animal group and in a wide variety of ­tissues and organs. 2 Evolutionary scheme of the organization of ZP genes in mammals, fish, amphibians, reptiles, and birds. ZP1–4 are found in mammals and other vertebrates, ZPd in amphibians and birds, and ZPax in fish, amphibians, and birds. , comparable locations are referred to as synteny). In addition, several ZP pseudogenes have been identified in mammals, for example, a ZP4 pseudogene in mice and ZP1 pseudogene in dogs and cows.

Zona pellucida domain proteins. Annu Rev Biochem 74, 83–114 (2005). Jovine L, Janssen WG, Litscher ES, Wassarman PM. The PLAC‐1 homology region of the ZP domain is sufficient for protein polymerization. BMC Biochem 7, 11–19 (2006). Monné M, Han L, Schwend T, Burendahl S, Jovine L. Crystal structure of the ZP‐N domain of ZP3 reveals the core fold of animal egg coats. Nature 456, 653–657 (2008). Monné M, Jovine L. A structural view of egg coat architecture and function in fertilization. Biol Reprod 85, 661–669 (2011).

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A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman


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