By Eveline S. Litscher, Paul M. Wassarman
This publication offers a coherent, transparent, and uniform presentation of structural, genetic, molecular, and biochemical details to be had for the zona pellucida area protein relatives, which effect pathologies reminiscent of infertility, deafness, and melanoma. moreover it:
- Details information regarding the constitution and serve as of the ZP area in ZPDC-proteins
- Provides illustrations of the association of ZPDC-proteins, the genes that encode the proteins, and examples of mutations within the ZP area that reason diseases
- Speculates as to the evolution of the ZP area and power therapeutics for ailments stemming from ZP area mutations
- Addresses mammalian and non-mammalian systems
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Extra resources for A Guide to Zona Pellucida Domain Proteins
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MZP3 vs. , mZP3 vs. 1). ZPD proteins that have diverse functions are found in every major animal group and in a wide variety of tissues and organs. 2 Evolutionary scheme of the organization of ZP genes in mammals, fish, amphibians, reptiles, and birds. ZP1–4 are found in mammals and other vertebrates, ZPd in amphibians and birds, and ZPax in fish, amphibians, and birds. , comparable locations are referred to as synteny). In addition, several ZP pseudogenes have been identified in mammals, for example, a ZP4 pseudogene in mice and ZP1 pseudogene in dogs and cows.
Zona pellucida domain proteins. Annu Rev Biochem 74, 83–114 (2005). Jovine L, Janssen WG, Litscher ES, Wassarman PM. The PLAC‐1 homology region of the ZP domain is sufficient for protein polymerization. BMC Biochem 7, 11–19 (2006). Monné M, Han L, Schwend T, Burendahl S, Jovine L. Crystal structure of the ZP‐N domain of ZP3 reveals the core fold of animal egg coats. Nature 456, 653–657 (2008). Monné M, Jovine L. A structural view of egg coat architecture and function in fertilization. Biol Reprod 85, 661–669 (2011).
A Guide to Zona Pellucida Domain Proteins by Eveline S. Litscher, Paul M. Wassarman