John Henderson's A Life of Ernest Starling PDF

By John Henderson

ISBN-10: 0195177800

ISBN-13: 9780195177800

Ernest Starling (1866-1927) was once pre-eminent within the golden age of British body structure. His identify is generally linked to his “Law of the Heart,” yet his discovery of secretin (the first hormone whose mode of motion used to be defined) and his paintings on capillaries have been extra vital contributions. He coined the observe 'hormone' 100 years in the past. His research of capillary functionality proven that equivalent and contrary forces stream around the capillary wall--an outward (hydrostatic) strength and an inward (osmotic) strength derived from plasma proteins.

Starling’s contributions include:
*Developing the "Frank-Starling legislation of the Heart," provided in 1915 and converted in 1919.
*The Starling equation, describing fluid shifts within the physique (1896)
*The discovery of secretin, the 1st hormone, with Bayliss (1902) and the advent of the idea that of hormones (1905).

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By John Henderson

ISBN-10: 0195177800

ISBN-13: 9780195177800

Ernest Starling (1866-1927) was once pre-eminent within the golden age of British body structure. His identify is generally linked to his “Law of the Heart,” yet his discovery of secretin (the first hormone whose mode of motion used to be defined) and his paintings on capillaries have been extra vital contributions. He coined the observe 'hormone' 100 years in the past. His research of capillary functionality proven that equivalent and contrary forces stream around the capillary wall--an outward (hydrostatic) strength and an inward (osmotic) strength derived from plasma proteins.

Starling’s contributions include:
*Developing the "Frank-Starling legislation of the Heart," provided in 1915 and converted in 1919.
*The Starling equation, describing fluid shifts within the physique (1896)
*The discovery of secretin, the 1st hormone, with Bayliss (1902) and the advent of the idea that of hormones (1905).

Show description

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Sample text

This time there was no increased lymph flow from the thoracic duct, and the lymph protein concentration was lower. This was real progress. It was clear that: (1) the liver was normally contributing the greater part of the lymph flow to the thoracic duct, and (2) that there was something different about the lymph derived from the liver. Could it have a higher protein content? It did, and it became clear that lymph protein increased when the proportion of liver lymph increased. There was no need to involve any secretory process in lymph formation in this situation; the different permeability of liver and intestinal capillaries to proteins could satisfactorily explain the findings.

Starling's main argument in this paper involves the increase in urine flow (diuresis) resulting from injecting glucose into the circulation. By producing glucose diuresis in anesthetized dogs, he lowered the osmotic pressure of urine to that of plasma. He argues that this can only occur if urine is formed at the glomerulus by filtration alone. It comes as no surprise to learn that Heidenhain had previously proposed an active process to occur at the glomerulus (analogous to his proposed active secretion by capillaries in the formation of lymph).

In 1903 Bayliss assumed the senior post, and held it until 1922—the longest tenure ever recorded. It meant that, between them, Bayliss and Starling were secretaries at the Society from 1896 to 1922. The senior secretary was—and still is—the chief executive officer of the society. Meanwhile, poor Hopkins was not getting on too well with the Guy's administration. Like Starling, he was expected to re-apply regularly for his post. In 1897 he seemed to have even more teaching than Starling, for he was a demonstrator in both physiology and chemistry with responsibilities in public health and toxicology.

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A Life of Ernest Starling by John Henderson


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